Determinants and clinical implications of chromosomal instability in cancer
نویسندگان
چکیده
منابع مشابه
Chromosomal instability and human cancer.
Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell. A major question in cancer genetics is whether genetic instability is a c...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2018
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2017.198